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It is important to note that statins are safe in NAFLD and should not be withheld when clinically indicated for cardiovascular risk reduction
Many patients on these medications complain of GERD
At therapeutic doses (2.5 mg and above), this dual activation works as intended
Besides, polyphenols also influence other mechanisms which tend towards improvement of muscle performance, for instance mitochondrial biogenesis comprises of two methods, either stimulating stress-related cell signaling pathways, increasing expression of genes encoding cytoprotective proteins such as nuclear respiratory factor 2 (NRF2) where variants of the NRF2 gene have been associated with endurance performance, or modulating muscle function and mitochondrial biogenesis by upstream regulation of sirtuins (SIRT1) and peroxisome proliferator-activated receptor coactivator (PGC-1) activity (Somerville et al
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